Figure 1
Enhanced proliferation of hematopoietic progenitor cells in Dmtf1−/− mice. BM-MNCs (A) or sorted KSLs (B) from WT, Dmtf1-KO, or Het mice were cultured with cytokines in methylcellulose medium for 10 days (n = 3) *P < .01 and **P < .05. (C) Representative dot plots showing MPPs (CD34+135+KSL), ST-HSCs (CD34+135−KSL), and LT-HSCs (CD34−135−KSL) in WT and Dmtf1-KO BM. (D) Quantification of the absolute number of KSLs, MPPs, ST-HSCs, and LT-HSCs and (G) quantification of the absolute number of progenitors (c-Kit+ and Sca1+) expressed as average ± SD per femur (n = 6). *P < .03 and *P < .05. (E) Absolute numbers of slamKSL (CD48−CD150+KSL) and (F) CD34− slamKSL expressed as average ± SD per femur (n = 7).

Enhanced proliferation of hematopoietic progenitor cells in Dmtf1−/− mice. BM-MNCs (A) or sorted KSLs (B) from WT, Dmtf1-KO, or Het mice were cultured with cytokines in methylcellulose medium for 10 days (n = 3) *P < .01 and **P < .05. (C) Representative dot plots showing MPPs (CD34+135+KSL), ST-HSCs (CD34+135KSL), and LT-HSCs (CD34135KSL) in WT and Dmtf1-KO BM. (D) Quantification of the absolute number of KSLs, MPPs, ST-HSCs, and LT-HSCs and (G) quantification of the absolute number of progenitors (c-Kit+ and Sca1+) expressed as average ± SD per femur (n = 6). *P < .03 and *P < .05. (E) Absolute numbers of slamKSL (CD48CD150+KSL) and (F) CD34 slamKSL expressed as average ± SD per femur (n = 7).

Close Modal

or Create an Account

Close Modal
Close Modal