RAEC assay results. (A) Grafted analogs of SFTI-1 with linear LAM and linear OPN. (B) Grafted analogs of SFTI-1 with linear QK. (C) Grafted analogs of MCoTI-II with linear LAM and linear OPN. The after peptide concentrations were: SFTI-1, linear LAM, and SFTI-LAM: 161μM; linear OPN, SFTI-OPN, and MCo-OPN: 5μM; linear QK and SFTI-QK: 0.1μM; FCS only; and negative control (medium only). Two asterisks indicate a significant change relative to the native cyclic scaffold; one asterisk indicates significance relative to negative control with P ≤ .05 and n ≥ 50. Error bars indicate SEM.