Effect of FLI1 and SMAD4 on patient survival. The effect of SMAD 4 level, divided into thirds, on overall survival is shown in panel A. The effect of the combination of FLI1 and SMAD4 level on overall survival is shown in panel B. Cohorts are divided based on whether FLI1 levels were equal to or above normal, and then on whether the SMAD4 level was in the low, middle, or highest third. Patients with below-normal FLI1 were removed for clarity. Survival of those with high FLI1 and high SMAD4 had inferior survival (median 33 weeks) compared with those with normal FLI1 and any level of SMAD4 (median 59 weeks; P = .0035), but equally poor survival as those with high FLi1 and medium SMAD4 (median 35 weeks; P = .52).