Integrative data analysis combining iron proteomics and microarray data. (A) Combination of categories a, b, c, and d. (B) Combination of categories e, f, g, and d. Category definitions are as follows: a, proteins up-regulated by hemin in Hepa1-6 cells in pSILAC experiments; b, proteins down-regulated by DFO in Hepa1-6 cells in pSILAC experiments; c, proteins up-regulated in IRP-deficient BMDMs (pSILAC experiments); d, IRP target mRNAs detected by IPs and microarrays; e, proteins down-regulated by hemin in Hepa1-6 cells in pSILAC experiments; f, proteins up-regulated by DFO in Hepa1–6 cells in pSILAC experiments; and g, proteins down-regulated in IRP-deficient BMDMs (pSILAC experiments).