Figure 2
Figure 2. The 1933x mutation in MYH9 reduces NK-cell killing. Cytotoxic activity of the YTS NK cell line stably expressing a 1933x myosin IIA-GFP fusion protein was compared with YTS cells expressing wild-type myosin IIA-GFP in 51Cr-release assays against 721.221 target cells. Results are listed as lytic units required for 10% lysis of target cells (LU10), and 1933x-GFP LU10 is normalized to myosin IIA-GFP for each assay. Results shown are the mean of 3 experiments and error bars indicate SD.

The 1933x mutation in MYH9 reduces NK-cell killing. Cytotoxic activity of the YTS NK cell line stably expressing a 1933x myosin IIA-GFP fusion protein was compared with YTS cells expressing wild-type myosin IIA-GFP in 51Cr-release assays against 721.221 target cells. Results are listed as lytic units required for 10% lysis of target cells (LU10), and 1933x-GFP LU10 is normalized to myosin IIA-GFP for each assay. Results shown are the mean of 3 experiments and error bars indicate SD.

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