Effect of fondaparinux, enoxaparin, or heparin on the prothrombotic activity of PCI catheter segments. Plasma was incubated with either (A) 1/1500 diluted RecombiPlasTin or (B) catheter segments, and the indicated concentrations of heparin (squares), enoxaparin (triangles), or fondaparinux (circles) for 10 minutes at 37°C. After initiating clotting by the addition of CaCl2, to 20mM, absorbance was monitored up to a maximum of 14 000 seconds, and time to clot was determined. The symbols represent the mean of ≥ 3 separate experiments, and the lines above and below the symbols reflect the SD.