Dynamics of nilotinib treatment response. The figure displays the kinetics of the leukemic cell burden in patients treated with first-line nilotinib for ≤ 66 months after diagnosis in early chronic phase. (A-D) The panels show the percentage of cancer cells (BCR-ABL1/BCR as measured by RQ-PCR) of 4 individual patients with CML (circles) and the fitted biphasic exponential model (red curves). This fitted model shows that there is a biphasic exponential depletion of leukemic cells, starting from the initiation of therapy. (E) The panel displays the median (orange circles) and quartiles of the nilotinib response data together with the fitted biphasic exponential model (red curves). See supplemental Figure 3 for all patient plots and model fitting.