REG3α concentrations in plasma samples from HCT patients of 2 independent validation sets. (A) University of Michigan patients (n = 871). (B) Regensburg, Germany, and Kyushu, Japan (n = 143). (C) Plasma REG3α concentrations in patients classified by GI symptoms and histologic diagnosis and categorized by conditioning regimen intensity. High-intensity regimens included: cyclophosphamide ± cytarabine, thiotepa, fludarabine and/or TBI; cyclophosphamide/VP-16/BCNU; busulfan + cytarabine, clofarabine, melphalan, cyclophosphamide/anasacrin, or cytarabine/cyclophosphamide; BCNU/VP-16/cytarabine/melphalan; TBI ± VP-16; melphalan. Moderate-intensity regimens included: fludarabine + busulfan or treosulfan ± TBI, melphalan, zevalin, or anasacrin/cytarabine; fludarabine ± TBI, melphalan, or cyclophosphamide; fludarabine/BCNU/melphalan; TBI. (D) Patients classified by symptoms and etiology (n = 675).