Amyloid deposits in the stomach of CMV-λ6 transgenic mice. Stomach sections were stained with Congo red and counterstained with hematoxylin visualized by brightfield (A) or polarized light microscopy (B). (C-D) Demonstration of immunohistochemical staining with anti–human λ and anti–human κ LC, respectively. (E) Negative staining EM of the contents of the stomach glands in the stomach of a transgenic mouse with Congo red positive deposits. Fibril diameters are approximately 10 nm. (F) Immunoblot for human λ LC in protein extracted from stomach amyloid deposits isolated by LCM (lane 1); serum from a transgenic mouse as a control (lane 2). The vertical line indicates that noncontiguous lanes from the same immunoblot image are displayed.