Kaplan-Meier curves for OS and EFS according to genotypes with statistical significance in multivariate analysis. All AML patients without cytogenetic prognostic markers could be divided into 3 prognostic groups using 4 marker combinations: low- risk, biallelic CEBPAm⁺ and/or NPM1m⁺/DNMT3Am⁻; high-risk, DNMT3Am⁺ and/or MLLm⁺; and intermediate, all remaining cases. Very few patients were repeatedly calculated in each group because of the concurrence of different mutations.