Pedigree of members of family 4, including 2 patients with MM and 2 with MGUS with a P-8 specific paraprotein carrying the hyperphosphorylated P-8. (A) The pedigree shows the family (family 4) of 2 patients with MM (III.1 and IV.1) and 2 patients with MGUS (IV.3 and IV.5), all having P-8 reactive paraproteins and carrying the hyperphosphorylated state of this protein. The pedigree is a part of a pedigree previously published.⁶  (B) Immunostaining of lysate bands derived from whole peripheral blood lysates from family members carrying wild-type (III.2, IV.2, IV.4, and V.1) and hyperphosphorylated P-8 (III.1, IV.1, IV.6, and V.2) after IEF. The numbers indicate family members in different generations.