A proposed mechanism for escape hematopoiesis in 6pLOH(+) AA. In AA, the targets of CTLs are the HSPCs that present some auto-antigen through particular class I HLA molecules, including HLA-A*02:01, A*02:06, A*31:01, and B*40:02. In the presence of these autoimmune insults, the HSPCs that lose their expression of the antigen-presenting HLA molecule as a result of CNN-LOH in 6p would acquire a growth advantage over other HSPCs expressing the relevant HLA, leading to clonal outgrowth of the 6pLOH(+) progenies.