ATF5, ASNS, and ASS1 gene polymorphisms and derived haplotypes. Haploview LD displays, linear representation and derived haplotypes for the selected ATF5 (A), ASNS (B), and ASS1 (C) polymorphisms. The linear display refers to all initially selected SNPs, and haploview LD (with pairwise r²) refers to SNPs with MAF ≥ 5%. MAF in the control population is given below the position of each SNP. SNPs excluded from the analysis of ALL patients because of pairwise r² ≥ 87% are indicated by asterisks, and those retained in the analysis are indicated by arrows. Haplotypes (with a frequency ≥ 3%) derived from tag SNPs are arbitrarily numbered. The frequency in controls is given next to each haplotype. Note that for ATF5, only the haplotypes in the promoter and 5′UTR are listed (the allele defining each haplotype is underlined) because of their correspondence with functional assay performed (see Figure 3).