Schematic representations of the location of somatic mutations identified in the BCORL1 gene. (A) Examples of sequence chromatograms showing inactivating somatic mutations of BCORL1 in blast cells (bottom panels) but not in their matched normal buccal mucosa (top panels). (B) Schematic of somatic mutations identified in the BCORL1 gene in primary AML cells and AML cell lines. Red arrows indicate truncating mutations; and black arrows, missense mutations. NLS indicates nuclear localization signal; LXXLL, Leu-Xaa-Xaa-Leu-Leu motif; ANK, tandem ankyrin repeats; aa, amino acids; and CtBP, C-terminal binding protein.