KSHV latent infection affects junctional integrity. HUVEC and KSHV-HUVEC were grown on coverslips, fixed, permeabilized, and stained with an antibody against VE-cadherin (A), β-catenin (B), and Rac1-GTP (C). Magnification, ×63, oil-immersion microscope. Bottom of panel A shows magnification (2.5×) of white box inset.