Effect of FXa-I16T on safety parameters. (A-C) HB mice (n = 5-12 per group) were injected with PBS (♢) or FXa-I16T 450 µg/kg (▲), and at the indicated time intervals, blood was collected and the following parameters were measured: (A) platelet count, (B) D-dimer, and (C) TAT. (D) HB mice (n = 5-7 per group) were injected with different amounts of FXa-I16T, and blood was collected 10 minutes after injection. In all panels, the dashed line represents values obtained with wt-mice. All values are presented as mean ± SEM.