Concept diagram for testing of recombinant CD32a mAbs in FCGR2A mice for protection against IC-mediated shock, thrombocytopenia, and thrombosis. (A) The CD40L antibody, M90, forms ICs with its trimeric ligand, CD40L. (B) The Fc regions of M90 ICs cluster platelet CD32a, causing robust activation. (C) CD32a-blocking mAbs such as IV.3, AT-10, and MDE-8 can prevent an IC from engaging CD32a.