Survival according to FLT3 and NPM1 mutation status. (A) EFS for patients with FLT3-ITD compared with FLT3-ITD–negative patients. (B) OS for patients not treated with SCT (stem cell transplantation) in first complete remission (CR1): patients with FLT3-ITD compared with FLT3-ITD–negative patients. (C) EFS for patients with FLT3-TKD mutations compared with wt FLT3-TKD patients. (D) EFS for patients with NPM1 mutations compared with wt NPM1 patients. (E) EFS for patients stratified on FLT3-ITD and NPM1 mutation status.