Impact of NOTCH1/FBXW7 mutational status on adult T-ALL patients outcome according to the GRAALL-2003 versus GRAALL-2005 trials. (A) EFS and (B) OS. Kaplan-Meier analyses show that in both trials GRAALL-2003 and GRAALL-2005 patients with mutated NOTCH1 and/or FBXW7 (solid lines) have a significantly lower risk of death or relapse than those with unmutated NOTCH1/FBXW7 (dashed lines).