Impact of NOTCH1/FBXW7 mutational status on adult T-ALL patients outcome according to the LALA-94 versus GRAALL trials. (A) EFS and (B) OS. Kaplan-Meier analyses, shown within the GRAALL trial a highly significantly better EFS and OS of patients with mutated NOTCH1 and/or FBXW7 (black line) compared with unmutated NOTCH1/FBXW7 patients (dashed line).