DFA of TTFT ≥ 5 years versus TTFT < 5 years. Graphic representation of select cytokines determined by DFA analysis to maximally discriminate 3 groups: CLL patients with TTFT ≥ 5 years, CLL patients with TTFT < 5 years, and healthy subjects. DFA results are visualized on a multidimensional plot with roots serving as coordinates and class discrimination power represented by distance between groups. The cytokines comprising root 1 and root 2, sorted by their discriminated capability, are CCL3, IL-5, GM-CSF, IL-8, IL-15, CCL2, IL-10, IL-12, IFNα, IFNγ, and IL-2.