LCH bone lesions may remodel if margins remain intact. These cases highlight the potential for even very large bone lesions to remodel following disease resolution. (A) Skull CT scans before and after chemotherapy in a patient with multifocal bone LCH. Remodeling following systemic chemotherapy nearly normalizes bone structure in a patient with significant skull lesions. This patient did not have any curettage or excisional surgery in the skull. (B) Brain MRI in a patient with multifocal bone LCH before and after complete excision with placement of mesh grafts. Complete excision of LCH lesion with margins into healthy bone inhibits potential for remodeling. Following resections and successful chemotherapy, skull defects persist.