Summary of roles of miR-135b in ALCL pathogenesis. The present study demonstrates that NPM-ALK induces LEMD1 and miR-135b expression through STAT3 in ALCL and that miR-135b targets FOXO1 and two versatile Th2 regulators, GATA3, and STAT6, rendering the IL-17–producing immunophenotype to ALCL.