Figure 3
Figure 3. The HSPC compartment of Tgfb2+/− mice is hyporesponsive to FLT3L in vivo. Fold increase in LSK cell number, BM and spleen cellularity, common lymphoid progenitors (CLPs; lineage−IL7Rα+KitloSca1lo), common dendritic progenitors (CDPs, lineage−KitloFLT3+CD115+) in the BM, and LSK cells and DCs (CD11c+) in the spleen in Tgfb2+/− mice and wt littermates after 10 days of FLT3L treatment in vivo. Data are presented as fold expansion in FLT3L-treated mice compared with controls treated with MSA only, from 3 independent experiments, each including 2-4 mice per group and per genotype, with 3 different batches of FLT3L.

The HSPC compartment of Tgfb2+/− mice is hyporesponsive to FLT3L in vivo. Fold increase in LSK cell number, BM and spleen cellularity, common lymphoid progenitors (CLPs; lineageIL7Rα+KitloSca1lo), common dendritic progenitors (CDPs, lineageKitloFLT3+CD115+) in the BM, and LSK cells and DCs (CD11c+) in the spleen in Tgfb2+/− mice and wt littermates after 10 days of FLT3L treatment in vivo. Data are presented as fold expansion in FLT3L-treated mice compared with controls treated with MSA only, from 3 independent experiments, each including 2-4 mice per group and per genotype, with 3 different batches of FLT3L.

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