In vivo antimyeloma effect of INK128. Vehicle, rapamycin, or INK128 was administered by oral gavage at 1 mg/kg/d for 10 days. (A) Detection of CD138⁺ cells in the BM of mice assessed by flow cytometry. (B) Nanofluidic proteomic immunoassay analyses for Akt, p-4EBP1, and caspase-3 were performed in CD138⁺ cells isolated from femurs of 9 mice.