Effect of INK128 on adhesion of MM cells. Adhesion assays with MM1S and OPM2 in the presence or absence of rapamycin (25-100nM) or INK128 (25-100nM). (A) Adhesion of MM cells to primary fibronectin. (B) Adhesion of MM cells to primary BMSCs. (C) Adhesion of MM cells to HUVECs. All data represent means ± SD of triplicate experiments. (D) Effect of rapamycin and INK128 on OPM2 cell homing after tail-vein injection in mice detected by circulating OPM2 cells using in vivo flow cytometry. All data represent means ± SD of triplicate experiments.