American Society of Hematology

Figure 3

$Figure 3. Genetic complexity and convergent evolution in patient CLL11. Different mutations affecting the same genes were identified in 2 independent subclones. Subclone A had mutations in NOTCH1 (p.Q2403X) and DDX3X (p.S62Lfs*32). Subclone B showed subclonal mutations in NOTCH1 (p.S2492X and p.P2514Rfs*4) and DDX3X (p.V345Vfs*19), and a frameshift deletion in BIRC3 (p.Y533Yfs*34). The horizontal axis represents the timeline of sample collection from prebaseline to baseline to relapse. The vertical axis represents the relative abundance of mutations in subclones. The approximate allelic fractions are shown for each mutation at different time points.$

Genetic complexity and convergent evolution in patient CLL11. Different mutations affecting the same genes were identified in 2 independent subclones. Subclone A had mutations in NOTCH1 (p.Q2403X) and DDX3X (p.S62Lfs*32). Subclone B showed subclonal mutations in NOTCH1 (p.S2492X and p.P2514Rfs*4) and DDX3X (p.V345Vfs*19), and a frameshift deletion in BIRC3 (p.Y533Yfs*34). The horizontal axis represents the timeline of sample collection from prebaseline to baseline to relapse. The vertical axis represents the relative abundance of mutations in subclones. The approximate allelic fractions are shown for each mutation at different time points.

This Feature Is Available To Subscribers Only