Rates of recurrent malignancy and risk of early and late recurrent malignancy according to GVHD and immunosuppressive treatment conditions. (A) Results are shown as rates per patient-year during successive 90-day intervals after transplantation. Small symbols represent the actual relapse rates for each 90-day interval. The smoothed rates were plotted as curves for each condition defined by the history of GVHD and continuation or discontinuation of IST. Plots were not illustrated for patients without GVHD who continued IST beyond 12 months because of insufficient sample size. (B-C) Risk of early and late recurrent malignancy according to GVHD and immunosuppressive treatment conditions. *Number of patients at risk in the condition at any time during the period of analysis. †Hazard ratios were adjusted for disease, risk category, and total body irradiation. ‡Effects of discontinued IST were not analyzed beyond 18 months in patients without GVHD, because the reference group was too small.