Clustering of 274 pediatric AML cases based on the 126 most discriminative probe sets for NUP98/NSD1. Hierarchical clustering of 274 pediatric AML cases based on the 126 most discriminative probe sets (FDR-adjusted P value < .05) for NUP98/NSD1 AML is presented in a heat map. The 13 NUP98/NSD1 cases are indicated with a red vertical bar below the heat map; the other AML cases are indicated with a gray vertical bar. In the heat map, cells represent relative log 2 expression values and have been color-coded on a scale ranging from bright green (−2) to bright red (+2), with black indicating no change relative to the median. Besides clustering of the NUP98/NSD1 cases, a group of other AML cases show a partly similar gene expression profile mainly based on the highly expressed HOXB probe sets, indicated by the gray bar at the right of the heat map.