NUP98/NSD1 clearly identifies a poor prognostic subgroup within pediatric and adult FLT3/ITD-positive AML. Survival curves of the pediatric cohort (A-C) and adult cohort (D-F) depicting the CIR according to the Kalbfleisch and Prentice method (A,D) and Kaplan-Meier estimates of the pEFS (B,E) and pOS (C,F) according to the NUP98/NSD1 and FLT3/ITD status.