Human MSCs and rhTSG-6 decreased the inflammatory response to zymosan-induced peritonitis. (A) Total cells in the lavage fluid. (B) Polymorphonuclear cells (PMN) in the lavage fluid. (C) Monocytes/macrophages in the lavage fluid. (D) Total cells in the lavage fluid harvested at 4 hours after administration of hMSCs, control hMSCs transfected with a scrambled siRNA (scr), hMSCs transfected with an siRNA for TSG-6, or rhTSG-6. Values are mean ± SD (n = 5 mice per time point; *P < .05; **P < .005; ***P < .0005).