Global translation in SBDS-deficient cells. (A) Global translation in K562/shSBDS-3 and K562/SCR was studied by measuring incorporation of ³⁵S-methionine/cysteine into equal amounts of newly synthesized trichloroacetic acid-precipitable peptides. Data are the mean ± SE of 3 experiments. Statistically significant results using t test: *P < .05. The ratios of the knockdown cells to control are presented in percentages. (B) Global translation in stable SBDS-knockdown cells after reintroduction of SBDS. Data are the mean ± SE of 3 experiments. *P < .05, statistically significant results using 1-way ANOVA and Tukey test for multiple means against both S-3 + YPET and S-3 cells.