Figure 3
Figure 3. Widespread expression of Kb-LTFNYRNL, but not LTFNYRNL without Kb, blunts the accumulation of TetH60+ cells. Kb−/−, actH60→actH60, actH60.Kb−/−→actH60.Kb−/−, actH60→actH60.Kb−/−, and actH60.Kb−/−→actH60 mice were irradiated and reconstituted with 6 × 106 BM cells, 2.4 × 106 CD8 cells, and 105 CD4 cells from C3H.SW mice. (A) Representative flow cytometry from day 14 (gated on Ly9.1+CD8+ cells). (B) Total numbers of Ly9.1+CD8+ TetH60+ cells per spleen at day 14. P = .0571, comparing actH60→actH60 to actH60→actH60.Kb−/− mice.

Widespread expression of Kb-LTFNYRNL, but not LTFNYRNL without Kb, blunts the accumulation of TetH60+ cells. Kb−/−, actH60→actH60, actH60.Kb−/−→actH60.Kb−/−, actH60→actH60.Kb−/−, and actH60.Kb−/−→actH60 mice were irradiated and reconstituted with 6 × 106 BM cells, 2.4 × 106 CD8 cells, and 105 CD4 cells from C3H.SW mice. (A) Representative flow cytometry from day 14 (gated on Ly9.1+CD8+ cells). (B) Total numbers of Ly9.1+CD8+ TetH60+ cells per spleen at day 14. P = .0571, comparing actH60→actH60 to actH60→actH60.Kb−/− mice.

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