Alterations in proteasome gene expression and favorable and unfavorable genes. (A) Bar plots of alterations in proteasome (PSM) gene expression within 48 hours of test-dosing with Bz in TT3 versus dexamethasone (Dex) in the control arm of TT2, thalidomide (Thal) in the experimental arm of TT2, lenalidomide (Len) in a phase 2 trial and melphalan (Mel) in TT4 (applied 48 hours after Bz test-dosing). Within each plot, the heights of the bars indicate the mean expression changes within 48 hours of drug administration; the vertical line on each bar represents a 95% confidence interval, indicating significant (or nonsignificant) changes when not crossing (or crossing) the x-axis. These bar plots show that the PSM genes were uniquely altered significantly by Bz but not by the other agents. (B) Total number of favorable/unfavorable genes and the genes overlapping in the GEP70 and GEP80 models.