Figure 3
Effects of SHP-2 knock-down in KCL22-R. Effects of 5μM IMA treatment in KCL22-RSHP2− and KCL22-RSh−Control on cell viability assessed by trypan blue exclusion (A), on apoptosis induction assessed by Annexin V/PI test (B), and on cell proliferation assessed by MTS assay (C). Results are expressed as mean ± SD of 3 independent experiments. (D) Signaling pathway analysis in KCL22-RSh−Control (referred as KCL22-RC in the figure) and KCL22-RSHP2− cell lines after exposure to 1μM IMA for 30 minutes. Cell extracts are subjected to WB analysis with the use of the specified antibodies.

Effects of SHP-2 knock-down in KCL22-R. Effects of 5μM IMA treatment in KCL22-RSHP2− and KCL22-RSh−Control on cell viability assessed by trypan blue exclusion (A), on apoptosis induction assessed by Annexin V/PI test (B), and on cell proliferation assessed by MTS assay (C). Results are expressed as mean ± SD of 3 independent experiments. (D) Signaling pathway analysis in KCL22-RSh−Control (referred as KCL22-RC in the figure) and KCL22-RSHP2− cell lines after exposure to 1μM IMA for 30 minutes. Cell extracts are subjected to WB analysis with the use of the specified antibodies.

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