Levels of let-7a and miR-16 and survival in patients with MDS and control subjects. Distributions of let-7a and miR-16 plasma levels in 76 healthy control subjects (A-B) and 50 MDS patients (C-D), along with Kaplan-Meier curves showing (E) OS by IPSS risk score (P = .022), (F) PFS by IPSS risk score (P = .063), (G) OS by let-7a level (P < .001), (H) PFS by let-7a level (P < .001), (I) OS by miR-16 level (P = .001), and (J) PFS by miR-16 level (P < .001). INT indicates intermediate.