TFS of CLL patients according to a prognostic scoring system, including the sFLC(κ + λ) parameter. Kaplan-Meier curves show the probability of remaining treatment-free for CLL cases subdivided according to a scoring system designed to evaluate unfavorable negative prognostic biomarkers: 1 point was assigned to each unfavorable prognostic marker [ZAP-70 expression, FISH abnormalities, Binet stage, and sFLC(κ + λ)], and the final score was given by the sum of the unfavorable markers present. A total of 262 patients were analyzed producing the following scores: 104 cases scored 0 (low risk), 79 scored 1 (low-intermediate risk), 56 scored 2 (intermediate-high risk), and 23 cases scored 3 or 4 (high risk) with a 3-year TFS of 94.8%, 84.5%, 61.6%, and 21.1%, respectively.