Figure 3
Kinetics of thrombocytopenia. Mean ± SEM platelet values from each treatment day during induction (romidepsin, bortezomib, and dexamethasone) and maintenance therapy (romidepsin). (A) Kinetics of thrombocytopenia during induction (all patients). The mean nadir of the platelet count (48 × 109/L) occurred on cycle 2, day 15 of induction. (B) Kinetics of thrombocytopenia during induction and maintenance in patients who went on to receive maintenance romidepsin (n = 12). Mean ± SEM platelet values from each treatment day during maintenance therapy (romidepsin). The mean nadir of the platelet count (154 × 109/L) occurred on cycle 3, day 22.
