Hepcidin traits and iron parameter mean levels in individuals from subset 1 classified according to MT2 genotypes (AA, AV, and VV). Hepcidin (A), hepcidin/ferritin ratio (B), hepcidin/transferrin saturation ratio (C), serum iron (D), and transferrin saturation (E) are shown. Data are expressed as mean values and are corrected by sex, age, squared age, and interaction by ANOVA (95% confidence intervals are shown). VV indicates homozygotes for the TMPRSS6 alleles encoding valine; AA, homozygotes for the TMPRSS6 alleles encoding alanine; and AV, compound heterozygotes for the 2 alleles. P values refer to comparison between AA and VV homozygotes; *P < .05; **P < .0005.