Schematic representation of 3 archetypes of NUP98 fusions. (A) NUP98-HD fusion protein. (B) NUP98-coiled-coil motif fusion protein. (C) Three subgroups of NUP98 oncoproteins that potentially modify chromatin via coiled-coil domain (CCD), SET, or PHD finger motifs. The GBD is represented by a blue box, the GLFG repeats are shown as vertical blue lines, the HD domain is shown as an orange box, the CCD is shown as coils, the SET domain is shown as diamonds, and the PHD domain is shown as a hexagon.