SET antagonism is cytotoxic to CLL cells and inhibits NHL cell growth in vitro. (A) Dose-response curves for COG445 treatment of CLL cells from 7 patients or normal B cells from 5 volunteers. (B) Dose-response curves for COG449 treatment on CLL cells from 7 patients. (C) Raji NHL cells were transduced with SET shRNA or control lentivirus, and knockdown was assessed by Western blotting from 2 samples of each. (D) Growth of Raji cells from panel C was assessed 72 hours after knockdown using a tetrazolium assay and demonstrated that SET antagonism inhibited growth. **P < .01. (E) Growth inhibition of Raji cells treated with the indicated levels of COG449 for 72 hours. (F) Growth inhibition of Ramos cells treated with the indicated levels of COG449 for 72 hours. *P < .05