Clinical outcome in upfront vaccination (group A). (A) Kaplan-Meier curves of progression-free survival (PFS) and treatment-free survival (TFS) after vaccination start (left panel) and lymphoma diagnosis (right panel). (B) Evolution of total lymphoma burden at 24 weeks after the first vaccination in relationship to cellular immune responses and lymphoma entity. R indicates patients who eventually achieved an objective partial remission; F, follicular lymphoma; M, mantle cell lymphoma; and m, marginal zone lymphoma. (C) Computed tomography scans of patient A119 with a near-complete disappearance of a disfiguring submandibular lymphoma manifestation.