Figure 2
Figure 2. Summary of human cell engraftment based on CD45 cell surface expression in the BM of nonobese diabetic/severe combined immunodeficiency/interleukin-2 γc receptornull mice transplanted with SLAM (CD150+CD48−), non-SLAM (not CD150+CD48−), or unfractionated CD34+ cells. Representative flow cytometry analysis after transplantation of 1 × 105 SLAM (A), non-SLAM (B), or unfractionated human CD34+ cells (C) derived from G-CSF MPB. (D) Control mice were injected intravenously with an equal volume of saline. (E) Summary of human cell engraftment after transplantation of G-CSF MPB cells from 3 independent donors in NSG mice. Each symbol represents one mouse, and the horizontal lines indicate the mean levels of human cell engraftment (n = 121 mice). Representative flow cytometry experiment after transplantation of 1 × 104 SLAM (F), non-SLAM (G), or unfractionated human CD34+ cells (H) derived from 8 pooled cord blood samples. (I) Control animals were transplanted with an equal volume of saline. (J) Summary of human cell engraftment after transplantation of cord blood derived cells in NSG mice (n = 28 mice).

Summary of human cell engraftment based on CD45 cell surface expression in the BM of nonobese diabetic/severe combined immunodeficiency/interleukin-2 γc receptornull mice transplanted with SLAM (CD150+CD48), non-SLAM (not CD150+CD48), or unfractionated CD34+ cells. Representative flow cytometry analysis after transplantation of 1 × 105 SLAM (A), non-SLAM (B), or unfractionated human CD34+ cells (C) derived from G-CSF MPB. (D) Control mice were injected intravenously with an equal volume of saline. (E) Summary of human cell engraftment after transplantation of G-CSF MPB cells from 3 independent donors in NSG mice. Each symbol represents one mouse, and the horizontal lines indicate the mean levels of human cell engraftment (n = 121 mice). Representative flow cytometry experiment after transplantation of 1 × 104 SLAM (F), non-SLAM (G), or unfractionated human CD34+ cells (H) derived from 8 pooled cord blood samples. (I) Control animals were transplanted with an equal volume of saline. (J) Summary of human cell engraftment after transplantation of cord blood derived cells in NSG mice (n = 28 mice).

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