The effect of pharmacogenetics-guided dosing on time to primary events. Kaplan-Meier plots represent the lack of association for attainment of first INR within therapeutic range (2.0-3.0) and first above-range INR (INR ≥ 4) among VKORC1 (A,C) and CYP2C9 (B,D) genotype groups after initiation with WRAPID nomogram. The statistic in each panel represents the log-rank P value for testing the equality of survival functions. WT indicates wild type.