Coadministration of BMS354825 and UCN-01 inhibits angiogenesis in vivo. Following the experiments described in Figure 6, cryosections of the excised tumors were stained by immunohistochemistry using antibodies specifically recognizing murine CD31, an established vascular endothelial marker. Images were captured at 20×/0.50 magnification in the superficial, central, and deep regions within tumors. For each region, areas marked by black squares (top panels) were amplified and shown in the bottom panels. Dashed lines correspond to the borders between tumor and muscle (m). Arrows indicate the dermal facets of tumors.