Figure 5
Figure 5. MAIT cells express ABCB1 and persist through chemotherapy. (A) Representative Vα7.2-CD161 staining of CD3+CD4−CD62L−CD95+ PBLs. (B-C) Representative ABCB1 (B) or Rh123 (C) staining according to Vα7.2-CD161 expression as gated in panel A. (A-C) n = 4. (D) Blood numbers of naive (CD45RA+CD27+) or memory (CD45RA−CD27+) CD4 or CD8 T (CD3+γδ−) and MAIT cells of breast cancer patients before (P1), during (P2), and after (P3) chemotherapy (6 cycles of anthracycline-containing regimen). All values were normalized to prechemotherapy.

MAIT cells express ABCB1 and persist through chemotherapy. (A) Representative Vα7.2-CD161 staining of CD3+CD4CD62LCD95+ PBLs. (B-C) Representative ABCB1 (B) or Rh123 (C) staining according to Vα7.2-CD161 expression as gated in panel A. (A-C) n = 4. (D) Blood numbers of naive (CD45RA+CD27+) or memory (CD45RACD27+) CD4 or CD8 T (CD3+γδ) and MAIT cells of breast cancer patients before (P1), during (P2), and after (P3) chemotherapy (6 cycles of anthracycline-containing regimen). All values were normalized to prechemotherapy.

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