Chemokine signature of osteoclasts. (A) Affymetrix CCL2, CCL7, CCL8, CCL13, CCL23, CXCL5, and CCL18 gene expression in BM CD34 cells (n = 5), BM stromal cells (n = 5), purified BM CD15 (n = 5), CD14 (n = 5), and CD3 cells (n = 5), osteoclasts (n = 7), normal memory B cells (n = 6), normal polyclonal plasmablasts (n = 7), normal BMPCs (n = 7), and purified myeloma cells from consecutive patients with MM (n = 206). (B) CCR2 expression in memory B cells, normal plasmablasts, and normal BM plasma cells from 7 healthy donors, 206 with MM, and 20 HMCL. The Affymetrix signal of the CCR2 probe set 206978_at is indicated on the y-axis. CCR2 expression in each sample is indicated by the height of the bar. Samples are ordered from the highest to lowest expression of CCR2 gene from left to right on the x-axis. The attached table shows the median value and range of Affymetrix signal and the percentage of samples with a present call.