Gene variants in NTRK1 and PEAR1 associated with platelet function after aspirin treatment and linkage disequilibrium at the locus. (A) EA ancestry and (B) African ancestry. In both figures, the top panel shows the strength of association between individual SNPs along the locus (genetic coordinates chromosome 1:155050166 to 155154850, NCBI build 36.3) and platelet function phenotypes. Col2 and 5 indicate aggregation to collagen 2 and 5 μg/mL, respectively; ADP2 and 10, aggregation to ADP 2 and 10μM, respectively; Epi2 and 10, aggregation to epinephrine 2 and 10μM, respectively. Red dotted line signifies Bonferroni corrected significance threshold (3.19 × 10−5); rs numbers across the top signify SNPs reaching the significance threshold (red font denotes significance for both ancestries, black font denotes significance for one ancestry). Chromosomal coordinates for the NTRK1 and PEAR1 genes within the locus are shown by blue bars. In both figures, the bottom panel shows linkage equilibrium among SNPs in the region. The pairwise strength of association between SNPs (D') is signified by depth of color of shaded areas (white = 0, dark red = 1.0). Areas within triangles signify LD blocks.
