ADAM10 inhibition enhances the growth-suppressing effects of the proteasome inhibitors bortezomib and MG132 in Jeko-1 cells. (A) Jeko-1 cells transfected with either scrambled or ADAM10 siRNA were treated with MG132 (1μM). At 24 hours after the MG132 treatment, the trypan blue exclusion assay was performed, and we found that ADAM10 siRNA enhanced the growth-suppressing effect of MG132 in Jeko-1 cells (P < .0001). (B) Jeko-1 cells transfected with either scrambled or ADAM10 siRNA treated with bortezomib (5nM). At 24 hours after the bortezomib treatment, the trypan blue exclusion assay was performed, and we found that ADAM10 siRNA enhanced the growth-suppressing effect of bortezomib in Jeko-1 cells (P < .0001 by ANOVA).