GPG-290 prevents thrombus development in the stenosis model without affecting leukocyte rolling. Stenosis of IVC was performed in WT mice. GPG-290 (100 μg/kg) or sterile saline was infused immediately after operation and again after 24 hours. Thrombi were harvested 48 hours after operation. Values for weight (A) and length (B) of the thrombi are shown with medians (horizontal bars). (C) Incidence of the thrombosis. Vehicle, n = 9; GPG-290, n = 11. (D) Leukocyte rolling was recorded in the same mesenteric vein (diameter 200-300 μm) before and after infusion of GPG-290 (5 mg/kg). No effect of GPG-290 on the number of rolling leukocytes was observed. Results are mean ± SEM, n = 4. (E) Representative photographs of rolling leukocytes in a mesenteric vein before and after infusion of GPG-290. White arrow indicates a rolling leukocyte. Bar, 50 μm.